Abstract:
Epicutaneo-caval catheters are vital in neonatal care but prone to occlusion and infection. This pilot study evaluated whether a one-hour saline lock, combined with proper flushing and anti-reflux connectors, affects catheter patency in neonates. Catheter patency was assessed using infusion pressure (pre and post lock) as a surrogate measure. These findings support the feasibility and safety of short lock periods, thereby laying the groundwork for future use of antimicrobial lock solutions in neonatal care.
Reference:D’Andrea V, Prontera G, Vento G. Feasibility LOck sOlutionS for Epicutaneo-caval catheters in Neonates: a “LOOSEN” pilot study. J Hosp Infect. 2025 Aug 11:S0195-6701(25)00230-0. doi: 10.1016/j.jhin.2025.07.014. Epub ahead of print. PMID: 40803382.