"During infusion, the patient developed pain, swelling, and erythema at the catheter site; these findings were attributed to local irritation and the infusion continued. After 18 hours, the catheter was removed and placed in her contralateral hand, and subsequent doses were given without incident" Vlahos et al (2026).
Iatrogenic calcinosis cutis from calcium gluconate extravasation

Abstract:

During infusion, the patient developed pain, swelling, and erythema at the catheter site; these findings were attributed to local irritation and the infusion continued. After 18 hours, the catheter was removed and placed in her contralateral hand, and subsequent doses were given without incident. The patient remained afebrile and had no systemic symptoms, neurovascular deficits, or skin injury, and was discharged on postoperative day 2.

Reference:

Vlahos F, Giannakikou I. Iatrogenic calcinosis cutis from calcium gluconate extravasation. Cleve Clin J Med. 2026 Aug 3;93(8):454-456. doi: 10.3949/ccjm.93a.25112. PMID: 42547274.