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Central venous catheter-related deep vein thrombosis in DKA

"If CVC placement cannot be avoided, preventive anticoagulation should be considered, but further studies are needed to establish a proper protocol" Mompontet et al (2025).

"If CVC placement cannot be avoided, preventive anticoagulation should be considered, but further studies are needed to establish a proper protocol" Mompontet et al (2025).

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Central venous catheter-related deep vein thrombosis in DKA

Abstract:

Introduction: Type 1 diabetes (T1D), particularly diabetic ketoacidosis (DKA), is believed to induce a prothrombotic state, mainly due to activation of the coagulation system, platelets, and relative hypofibrinolysis.

Observations and discussion: A central venous catheter (CVC) can be necessary in cases of severe inaugural DKA in the pediatric intensive care unit (PICU). Children with a CVC are at increased risk of thrombosis, particularly before the age of three. Following a literature review and our experience in Toulouse (4 cases) of CVC-related thrombosis, we propose that CVC placement should be avoided as much as possible and alternative venous access should be preferred to minimize the risk of thrombosis.

Conclusion: If CVC placement cannot be avoided, preventive anticoagulation should be considered, but further studies are needed to establish a proper protocol.


Reference:

Mompontet M, Breinig S, Morin C. Central venous catheter-related deep vein thrombosis in severe inaugural diabetic ketoacidosis: A four case-report and literature review. Arch Pediatr. 2025 Mar 18:S0929-693X(25)00051-X. doi: 10.1016/j.arcped.2025.01.003. Epub ahead of print. PMID: 40107906.

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