Extract:
“Target Controlled Infusion (TCI) represents a technique of intravenous anaesthetic drug administration where we aim a predictable concentration of the drug in a specific body compartment.
The technique uses a computer-controlled infusion pump which delivers the anaesthetic drugs based on patient’s parameters (height, weight, age, gender and others) in order to achieve a predicted plasmatic level (TCIp) or a specific site (brain) (TCIe) [1].
The main advantage of the system consists in theoretical calculations and application of precise doses. TCI is designed upon the three-compartmental pharmacokinetic model, maintaining the same level of sedation, and avoiding drugs accumulation. This delivery method could also reduce the intra-operative awareness, emphasising on patient safety. However, the practice showed that those theoretical facts may not be easily applied into clinical practice [2].
Reference:Szederjesi J. Target Controlled Infusion: an Anaesthetic Technique Brought in ICU. J Crit Care Med (Targu Mures). 2022 Feb 9;8(1):3-5. doi: 10.2478/jccm-2022-0001. PMID: 35274049; PMCID: PMC8852287.