First-dose antimicrobial reactions in OPAT patients
Abstract:
After receiving a monitored first-dose antimicrobial infusion at an infusion center, 6 of 93 (6%) patients enrolled in outpatient parenteral antimicrobial therapy services experienced an immediate reaction, none of which were consistent with immunoglobulin E-mediated reactions. These findings suggest it would be reasonable to forgo monitoring for most patients receiving first-dose intravenous antimicrobials outpatient.
Reference:Kovacik CN, Shah MD, Thomas TA, Eby JC. First-Dose Antimicrobial Infusion Reactions in Patients Enrolled in Outpatient Parenteral Antimicrobial Therapy Services. Open Forum Infect Dis. 2023 May 3;10(6):ofad239. doi: 10.1093/ofid/ofad239. PMID: 37305845; PMCID: PMC10249267.