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"Pilot randomized controlled trial (180 patients) of needleless connector decontamination" Rickard et al (2020).
Abstract:

Pilot randomized controlled trial (180 patients) of needleless connector decontamination. Central line-associated bloodstream infection occurred in 2% (1/61) of 70% isopropyl alcohol (IPA) wipe, 2% (1/59) of 70% IPA cap, and zero (0/58) infections in 2% chlorhexidine gluconate in 70% IPA wipe patients. Larger definitive trials are feasible and needed.

Reference:

Rickard CM, Flynn J, Larsen E, et al. Needleless connector decontamination for prevention of central venous access device infection: a pilot randomized controlled trial [published online ahead of print, 2020 Jul 28]. Am J Infect Control. 2020;S0196-6553(20)30731-8. doi:10.1016/j.ajic.2020.07.026

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