Abstract:
To prepare clinicians to treat extravasation of noncytotoxic vesicants with antidotes and thermal compresses, a literature review was performed to identify noncytotoxic vesicants and to create evidence and consensus-based recommendations. The stage of injury and vesicant’s mechanism of tissue injury dictate treatment. For a vasopressor extravasation, warm compresses and administration of a vasodilator are recommended. For osmolarity, pH, absorption refractory, and cytotoxic concentration-dependent vesicants, warm compresses and administration of hyaluronidase are recommended. Compared with potentially catastrophic costs of undertreatment, the cost of overtreatment is minimal.
Reference:
Ong J, Van Gerpen R. Recommendations for Management of Noncytotoxic Vesicant Extravasations. J Infus Nurs. 2020 Nov/Dec;43(6):319-343. doi: 10.1097/NAN.0000000000000392. PMID: 33141794.