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Activity of taurolidine lock solution against Candida auris – Full Text

"We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates" Reidenberg et al (2024).

"We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates" Reidenberg et al (2024).

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Activity of taurolidine lock solution against Candida auris

Abstract:

Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C. auris isolates. Taurolidine was highly active with a MIC50/MIC90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.

Reference:

Reidenberg BE, Jenkins SG, Crandon JL, Hurlburt E, Tan X, Rhomberg PR, Arends SJR, Pfaffle A. In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections. Antimicrob Agents Chemother. 2024 Jun 12:e0038124. doi: 10.1128/aac.00381-24. Epub ahead of print. PMID: 38864612.

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