“The American Academy of Allergy, Asthma, and Immunology (AAAAI) has recently released professional guidance that encourages the proactive delabeling of penicillin allergies in patients who are unlikely to truly be penicillin allergic as a mechanism to promote the use of beta-lactam antibiotics when appropriate.6 Nurses and pharmacists alike are well positioned to conduct patient-centric historic and clinical investigations that may facilitate penicillin allergy delabeling. This review seeks to present the clinical phenotypes with which a beta-lactam allergy may present, define the untoward effects that a fictitious penicillin allergy label may confer to a patient, and propose clinical investigational prompts for nurses and other allied health professionals when interacting with a patient that has a penicillin or other beta-lactam allergy in their medical history.”

Johannesmeyer HJ. Getting to the Bottom of a Patient’s Penicillin Allergy Label. J Infus Nurs. 2025 Jan-Feb 01;48(1):32-35. doi: 10.1097/NAN.0000000000000584. Epub 2024 Dec 26. PMID: 39760876.