Impact of blood sampling on anemia in PICU
Abstract:
Objectives: Fifty percent of children are anemic after a critical illness. Iatrogenic blood testing may be a contributor to this problem. The objectives of this study were to describe blood sampling practice in a PICU, determine patient factors associated with increased sampling, and examine the association among blood sampling volume, anemia at PICU discharge, and change in hemoglobin from PICU entry to PICU discharge.
Design: Prospective observational cohort study.
Setting: PICU of Sainte-Justine University Hospital.
Patients: All children consecutively admitted during a 4-month period.
Measurements and main results: Four hundred twenty-three children were enrolled. Mean blood volume sampled was 3.9 (±19) mL/kg/stay, of which 26% was discarded volume. Children with central venous or arterial access were sampled more than those without access (p < 0.05). Children with sepsis, shock, or cardiac surgery were most sampled, those with a primary respiratory diagnosis; the least (p < 0.001). We detected a strong association between blood sample volume and mechanical ventilation (H, 81.35; p < 0.0001), but no association with severity of illness (Worst Pediatric Logistic Organ Dysfunction score) (R, -0.044; p = 0.43). Multivariate analysis (n = 314) showed a significant association between the volume of blood sampled (as continuous variable) and anemia at discharge (adjusted OR, 1.63; 95% CI, 1.18-2.45; p = 0.003). We lacked power to detect an association between blood sampling and change in hemoglobin from PICU admission to PICU discharge.
Conclusions: Diagnostic blood sampling in PICU is associated with anemia at discharge. Twenty-five percent of blood losses from sampling is wasted. Volumes are highest for patients with sepsis, shock, or cardiac surgery, and in patients with vascular access or ventilatory support.
Reference:
François T, Sauthier M, Charlier J, Dessureault J, Tucci M, Harrington K, Ducharme-Crevier L, Al Omar S, Lacroix J, Du Pont-Thibodeau G. Impact of Blood Sampling on Anemia in PICU: A Prospective Cohort Study. Pediatr Crit Care Med. 2022 Apr 11. doi: 10.1097/PCC.0000000000002947. Epub ahead of print. PMID: 35404309.