Abstract:
Current guidelines for severe herpes simplex virus infection recommend 21 days of intravenous therapy. The thrice-daily administration of intravenous acyclovir makes it challenging to deliver as outpatient therapy. We describe 2 cases with confirmed or presumed neonatal herpes simplex virus encephalitis treated with acyclovir administered as a continuous-infusion at home and review the pharmacologic and clinical evidence for continuous infusions of acyclovir.
Reference:
O’Leary CK, Jones C, Bryant PA, Abo YN, Osowicki J, Gwee A. Feasibility of Continuous Infusions of Acyclovir. Pediatr Infect Dis J. 2020;39(9):830-832. doi:10.1097/INF.0000000000002692