“We present findings from our large-scale retrospective study on contrast media extravasation (CME) in computed tomography (CT) examinations. Over 3 years, we analysed 26,544 adult CT examinations with intravenous contrast media administered via a power injector to determine CME incidence and evaluate associated risk factors.

CME is a recognised complication of contrast-enhanced CT, potentially leading to severe outcomes in rare cases. Most instances result in mild, self-limiting symptoms like swelling, erythema and pruritus. However, severe outcomes, including compartment syndrome, extensive skin ulceration and tissue necrosis have been documented, occasionally necessitating surgical intervention.

Our study revealed an overall CME incidence of 0.11% (28/26,544), consistent with previously reported ranges.2 The majority were mild CME (89.3%), while 3 cases had moderate CME that presented with blistering, altered sensation and severe pain. None had severe CME. This low rate of approximately 1 in 915 patients underscores the relative safety of contrast-enhanced imaging procedures while highlighting the importance of identifying and mitigating risk factors.”

Teh HS, Srinivasan S, Lohan R, Loong MTM. Navigating the risks of contrast extravasation in CT scans: A 3-year study of 26,544 automated power injector cases. Ann Acad Med Singap. 2025 Feb 25;54(2):132-134. doi: 10.47102/annals-acadmedsg.2024270. PMID: 40071462.