BACKGROUND: Bloodstream infection (BSI) remains a considerable cause of morbidity and mortality for cancer patients. With a better understanding of it, better methods can be used. The primary objective of this study was to describe the characteristics of BSIs in our institution, and the second was to determine the possible risk factors associated with them.
MATERIALS AND METHODS: Data of cancer patients from 2009 to 2015 at our institution were included. Medical information and blood cultures were analyzed to determine the BSI rate. The χ and Fisher exact tests were used for categorical data and to determine risk factors associated with BSIs and pathogens.
RESULTS: A total of 565 (8.6%) events were diagnosed with BSIs. Although gram-negative bacteria (52.6%) were the most commonly isolated pathogens, gram-positive microorganisms (45.0%) were also prevalent. Oral and gastrointestinal organisms were common. Pathogens were more likely to be identified in patients with central venous catheters and in patients with prolonged neutropenia (P<0.05).
CONCLUSIONS: This study provides updated epidemiology in BSIs and helps with the prevention and management of suspected BSIs in vulnerable patients. Better anti-infection therapy could be provided to these patients based on the isolated pathogens.
Reference:Tang, Y.J., Su, Y., Cao, Q. and Gao, Y.J. (2020) Microbiologically Documented Bloodstream Infection in Children With Malignancies: A Single-center Experience. Journal of Pediatric Hematology/Oncology. February 24th2020 Feb 24. doi: 10.1097/MPH.0000000000001768. (Epub ahead of print).