Hepatic arterial infusion chemotherapy review

"The use of HAIC has become more prevalent over the last decade with more centers nation and worldwide developing HAI programs. Here, we review the history and origin of HAIC along with its evolution and outcomes of current applications" Baldwin et al (2026).

"The use of HAIC has become more prevalent over the last decade with more centers nation and worldwide developing HAI programs. Here, we review the history and origin of HAIC along with its evolution and outcomes of current applications" Baldwin et al (2026).

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Hepatic arterial infusion chemotherapy review

Abstract:

Hepatic artery infusion chemotherapy (HAIC) is a form of liver directed therapy for primary and metastatic cancers of the liver. Following the discovery that the hepatic artery supplies the majority of blood flow to hepatic tumors, studies have investigated the use of chemotherapeutics via this route as not only palliative, but therapeutic treatment. HAIC was initially designed exclusively for patients with unresectable colorectal liver metastasis (CRLM), however there is an emerging role for HAIC in patients with resectable CRLM and unresectable intrahepatic cholangiocarcinoma (ICC). The use of HAIC has become more prevalent over the last decade with more centers nation and worldwide developing HAI programs. Here, we review the history and origin of HAIC along with its evolution and outcomes of current applications.

Reference:
Baldwin XL, D’Angelica MI. Hepatic Arterial Infusion Chemotherapy Review. J Gastrointest Surg. 2026 Jun 18:102490. doi: 10.1016/j.gassur.2026.102490. Epub ahead of print. PMID: 42314798.