Extract:
“Peripherally inserted central catheters (PICCs) are widely used in patients with haematological malignancies due to their favourable risk benefit profile. However, catheter related thrombosis (CRT) remains a significant complication. PICCs with a port system (PICC-PORTs), fully implantable variants of PICCs, have emerged as a potentially less thrombogenic alternative, although comparative data in haematological malignancies are limited and guidelines offer no specific recommendations. Haematological malignancies inherently increase thrombotic risk due to disease related hypercoagulability and chemotherapy induced endothelial dysfunction. Lymphoproliferative disorders, including acute lymphoblastic leukaemia, Hodgkin and non9 Hodgkin lymphomas, have been associated with a higher incidence of upper extremity deep vein thrombosis (UEDVT). Moreover, there is no consensus on anticoagulation or validated risk scores to guide risk stratification in this population. This study aimed to prospectively assess CRT incidence in haematological malignancies, exploring potential associations with patient and device characteristics, and comparing outcomes between PICCs and PICC-PORTs.”
Reference:Cominacini M, De Marchi S, Magnani G, Piccinno E, Tosi F, Carbonare LD. Catheter Related Thrombosis in Haematological Malignancies: Insights from Ultrasound Screening of Peripherally Inserted Central Catheters. Eur J Vasc Endovasc Surg. 2025 Dec 18:S1078-5884(25)01270-5. doi: 10.1016/j.ejvs.2025.12.026. Epub ahead of print. PMID: 41421642.