Delayed presentation of amiodarone extravasation injury – Full Text

"In an acute setting, especially in unstable patients, the intravenous (IV) route of Amiodarone administration is preferred; however, it is not risk-free. One of the lesser-known but potentially serious complications of the intravenous route is extravasation, where the drug leaks into surrounding tissue" Rojony et al (2025).

"In an acute setting, especially in unstable patients, the intravenous (IV) route of Amiodarone administration is preferred; however, it is not risk-free. One of the lesser-known but potentially serious complications of the intravenous route is extravasation, where the drug leaks into surrounding tissue" Rojony et al (2025).

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Abstract:

Extract:

“Amiodarone is an antiarrhythmic medication, commonly used for treating supraventricular and ventricular arrhythmias. In an acute setting, especially in unstable patients, the intravenous (IV) route of Amiodarone administration is preferred; however, it is not risk-free. One of the lesser-known but potentially serious complications of the intravenous route is extravasation, where the drug leaks into surrounding tissue. While extravasation injuries are more frequently associated with long-term infusion therapies such as chemotherapy or hyperosmolar agents, amiodarone has also been linked to significant soft tissue damage, including skin necrosis.”

Reference:

Rojony R, Bareeqa SB, Singla S. Delayed presentation of amiodarone extravasation-induced skin necrosis: A case report with discussion on management. JAAD Case Rep. 2025 Jun 18;63:178-181. doi: 10.1016/j.jdcr.2025.06.006. PMID: 40933820; PMCID: PMC12418991.