CLABSI and CRBSI systematic review
Abstract:
Objective: Accurate effect estimates are needed to inform input parameters of health economic models. Central-line-associated bloodstream infections (CLABSIs) and catheter-related bloodstream infections (CRBSIs) are different definitions used for central-line bloodstream infections and may represent dissimilar patients, but previous meta-analyses did not differentiate between CLABSIs/CRBSIs. In this meta-analysis, we provided outcome effect estimates in CLABSI and CRBSI patients, compared to uninfected patients.
Methods: We searched PubMed, EMBASE and CINAHL from January 2000 to March 2024 for full-text studies reporting all-cause mortality and/or hospital length of stay (LOS) in adult inpatients with and without CLABSI/CRBSI. Two investigators independently reviewed all potentially relevant studies and performed data extraction. Odds ratio for mortality and mean difference in LOS were pooled using random-effects models. Risk of study bias was assessed using ROBINS-E.
Results: We included 36 studies. Sixteen CLABSI and 12 CRBSI studies reported mortality. The mortality odds ratios of CLABSIs and CRBSIs, compared to uninfected patients, were 3.19 (95% CI, 2.44, 4.16, I2=49%) and 2.47 (95% CI, 1.51, 4.02, I2=82%) respectively. Twelve CLABSI and eight CRBSI studies reported hospital LOS; only three CLABSI studies and two CRBSI studies accounted for the time-dependent nature of CLABSIs/CRBSIs. The mean differences in LOS for CLABSIs and CRBSIs compared to uninfected patients were 16.14 days (95% CI, 9.27, 23.01, I2=91%) and 16.26 days (95% CI, 10.19, 22.33, I2=66%) respectively.
Conclusion: CLABSIs and CRBSIs increase mortality risk and hospital LOSs. Few published studies accounted for the time-dependent nature of CLABSIs/CRBSIs, which can result in overestimation of excess hospital LOS.
Reference:
Elangovan S, Lo JJ, Xie Y, Mitchell B, Graves N, Cai Y. Impact of central-line-associated bloodstream infections and catheter-related bloodstream infections: a systematic review and meta-analysis. J Hosp Infect. 2024 Aug 14:S0195-6701(24)00269-X. doi: 10.1016/j.jhin.2024.08.002. Epub ahead of print. PMID: 39151801.