Abstract:
Alemtuzumab infusion is rarely associated with serious cardiac toxicity. We report a case of acute troponin-negative chest pain with dynamic T-wave changes, immediately following first infusion of alemtuzumab in a patient with multiple sclerosis. The chest pain and ECG (electrocardiogram) changes improved with cessation of alemtuzumab and conservative management. The presumed cause was infusion-associated cytokine release, but the precise mechanism is unknown.
Reference:
Ahrabian, D., Neill, L., Bell, R. and Leary, S.M. (2020) Acute cardiotoxicity associated with alemtuzumab infusion for multiple sclerosis. Multiple Sclerosis. April 16th. doi: 10.1177/1352458519855725. (Epub ahead of print).